Green nanotechnologies for cancer treatment - A review

Authors

  • Thiago Leonardo Sangalli Universidade Federal de Tocantins

DOI:

https://doi.org/10.20873/uftv9-12467

Abstract

Green nanoparticles are natural substrates extracted from biological resources available in nature, the aim of this study was to review the anticancer activity of NPs synthesized from green extracts against tumor cells. We selected 21 articles from the electronic database, PubMed and Cochrane, works published in the last 5 years, in English, Portuguese and Spanish. The results showed the anticancer potential of biogenic nanoparticles against different cancer cells, about 95% of the studies show some cytotoxic effect on the tumor. The most studied tumor cell lineage was of hepatic origin, 80% of the articles evaluated the result of NPs in hepatocellular carcinoma (HepG2), and obtained surprising results, the second most studied cell lineage was breast adenonocarcinoma (MC-7). Cytotoxicity in tumor cells was evaluated through the minimum inhibitory concentration (I50). and at the molecular level, the presence of apoptotic cells was observed, as well as an increase in intracellular reactive oxygen species (ROS) and expression of caspase proteins and a decrease in anti-apoptotic enzymes. It can be concluded that green NPs are an effective alternative in the treatment of cancer, however studies should evaluate the anticancer activity through in vivo studies in humans.

Published

2022-05-02

How to Cite

Sangalli, T. L. (2022). Green nanotechnologies for cancer treatment - A review. DESAFIOS - Revista Interdisciplinar Da Universidade Federal Do Tocantins, 9(1), 156–168. https://doi.org/10.20873/uftv9-12467

Issue

Section

Artigos