RELATO DE CASO
Lymphomatoid granulomatosis (LYG) is a rare extranodal Epstein-Barr virus (EBV) associated B-cell lymphoproliferative disorder. Most cases occur between the fourth and sixth decades of life and the male-to-female ratio is 2:1. The lung is the most frequently involved organ. Radiographically, pulmonary disease is characterized by multiple variable size nodules. Histologically, the lesions show angiocentricity, are rich in T cells, have large atypical B cells, lymphocytic infiltration of the vascular wall and a variable necrosis. LYG is a distinct entity that can usually be differentiated from other EBV-associated B-cell lymphoproliferative disorders on the basis of the combination of clinical presentation and histology. The authors described the case of a 53-year-old woman who was previously diagnosed with sarcoidosis, histoplasmosis, and later with non-Hodgikin B Lymphoma. The lungs presented diffuse alveolar damage, exsudative phase, and infiltration by lymphomatoid granulomatosis. The patient became unstable and died. Grading of these lesions is important because it dictates the treatment choice.
Keywords: Lymphomatoid granulomatosis, Epstein-Barr virus, pulmonary nodules.
Os autores declaram para os devidos fins de direito e obrigações, sob as penas previstas na Legislação vigente, que são autores/detentores dos Direitos Autorais do trabalho proposto nos termos dos artigos 28 a 33 da Lei Federal nº9.610 de 19 de fevereiro de 1998 (Lei dos Direitos Autorais).